Spatially integrated social science is a broad term used to describe the integration of space and place in social science research using Geographic Information Systems (GIS). It includes qualitative GIS approaches, such as geo-ethnology and geo-narratives, which combine qualitative social data with GIS and represent an emerging approach with significant potential for facilitating new insights into the dynamic interactions between mining companies and host communities. Mine operations are unique in their complexity, both in terms of the dynamic and diverse nature of issues and the requirement to integrate knowledge, theories, and approaches from a range of disciplines. In this paper we describe the potential for spatially integrated social science using qualitative GIS to understand the social impacts of mining. We review current literature and propose a framework that incorporates quantitative and qualitative knowledge across social and biophysical domains within a multi-user approach. We provide examples to illustrate how our approach could support past, present, and future assessment of socio-environmental systems in large-scale mining. We conclude by discussing the need for a multi-disciplinary approach to support decision makers and local stakeholders in considering complex social and environmental scenarios.